Synonym: Cyclodextrin HPBAvailable Packaging size - 1 kg / 5 kg / 10 kg / 25 kg General description:Cyclodextrins are cyclic oligosaccharides consisting of 6, 7, or 8 glucopyranose units, usually referred to as α-, β-, or γ-cyclodextrins, respectively. These compounds have rigid doughnut-shaped structures making them natural complexing agents. The unique structures of these compounds owe their stability to intramolecular hydrogen bonding between the C2- and C3-hydroxyl groups of neighboring glucopyranose units. The molecule takes on the shape of a torus with the C2- and C3-hydroxyls located around the larger opening and the more reactive C6-hydroxyl aligned around the smaller opening. The arrangement of C6-hydroxyls opposite the hydrogen bonded C2- and C3-hydroxyls forces the oxygen bonds into close proximity within the cavity, leading to an electron rich, hydrophobic interior. The size of this hydrophobic cavity is a function of the number of glucopyranose units forming the cyclodextrin.The solubility of natural cyclodextrins is very poor. In the late 1960's, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent.Application:The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.Available Packaging size - 1 kg / 5 kg / 10 kg / 25 kg About the Company GST Registration Date: 2017 Legal Status of Firm: Partnership Number of Employees: Upto 10 People Annual Turnover: 5 - 25 Cr company-description: Founded in the year 1988, Innovative has continued to expand the scope of its business as a chemical trading company with a constant focus on serving science, research and technology. Our business encompasses Life Sciences, Nutraceuticals, Organic/Inorganic Chemistry and Analytical Chemistry. To be able to better serve the science community we have further divided our business under two main business divisions. · Bulk Division Under this division we import, stock and supply more than 500 chemicals in bulk and offer very competitive wholesale pricing for the same. Our product range here mainly includes Amino Acids, Buffers, Carbohydrates, Biochemicals, Nucleosides, Organic Intermediates, Inorganic Salts, Stains and Indicators. This division mainly focuses on catering to all your Manufacturing, Repackaging and Pharmaceutical needs. · Laboratory Division Under this division we partner with some of the leading global companies as their business partners / authorized distributors to supply their products. Our brands portfolio consists of Sigma-Aldrich, Alfa-Aesar, Honeywell, TCI Japan, BDH/VWR, Combi-Blocks and many more. We are also able to supply Reference Standards of USP, EP, BP, TRC and many more renowned global companies. We are having more than 1500 items available from ready stock here and can supply over a million products on forward delivery basis. This division mainly focuses on catering to all your Laboratory, R&D, Q.C., Chromatography, Diagnostic and Research needs. As a trading company, we have focused each of our divisions on a strategic area with an eye on emerging trends. Overall we remain focused on sharpening our competitive edge and shall continue to pursue various capabilities of value for all our customers. Introducing ourselves as one of leading Chemical suppliers and presenting to all our customers with our Complete Product List has been solely our pleasure. We request you to kindly favour us with your valued inquiries from both, within this Catalog and otherwise. Rest assured your interests will be our first preference and of course, when it comes to service, the INNOVATIVE experience is unparalleled. Thanking you. Nilesh Shah Tushar Shah (Partners - Innovative)
