1. Chemical Identity Chemical Name: Estradiol Hemihydrate Synonyms: 17β-Estradiol Hemihydrate; Oestradiol Hemihydrate Molecular Formula: C₁₈H₂₄O₂ · ½H₂O Molecular Weight: 281.39 g/mol (anhydrous estradiol: 272.38 g/mol) Chemical Class: Natural estrogen; female sex hormone CAS Number: 50-28-2 (estradiol); hemihydrate form used in pharmaceutical preparations Estradiol hemihydrate is the hydrated crystalline form of 17β-estradiol, the principal endogenous estrogen in humans, widely used in pharmaceutical formulations due to improved stability and handling characteristics compared with the anhydrous form. 2. Structural Characteristics Estradiol hemihydrate consists of: The estrane steroid nucleus Phenolic hydroxyl group at C3, essential for estrogen receptor binding 17β-hydroxyl group, required for biological activity Water of crystallization (½ molecule) integrated in the crystal lattice The hemihydrate form does not alter pharmacological activity but enhances physical stability and manufacturability. 3. Physicochemical Properties Appearance: White or almost white crystalline powder Odor: Odorless Solubility: Practically insoluble in water Soluble in alcohol, acetone, and chloroform Melting Point: ~173-179 °C (may vary slightly due to hydration state) Lipophilicity: Moderate to high Stability: More stable crystalline form compared with anhydrous estradiol; sensitive to light 4. Mechanism of Action Estradiol hemihydrate acts as an estrogen receptor agonist: Dissociates to active 17β-estradiol in vivo Binds to estrogen receptors (ER-α and ER-β) Regulates transcription of estrogen-responsive genes Physiological effects include: Development and maintenance of female reproductive tissues Regulation of the menstrual cycle Maintenance of bone density Effects on lipid metabolism and vascular function About the Company GST Registration Date: 2023 Legal Status of Firm: Limited Company Number of Employees: "},{"DATA":"2023","TITLE":"Year of Establishment"},{"DATA":"","TITLE":"Standards \u0026 Quality Certifications"},{"DATA":"Limited Company (Ltd./Pvt.Ltd.)","TITLE":"Legal Status of Firm"},{"DATA":"","TITLE":""},{"DATA":"","TITLE":"Annual Turnover"},{"DATA":"","TITLE":"GST Partner Name"},{"DATA":"2023","TITLE":"GST Registration Year"},{"DATA":"Limited Company","TITLE":"GST Legal Status of Firm"},{"DATA":"Trader - Wholesaler/Distributor","TITLE":"GST Nature of 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Chemical Identity \n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eChemical Name:\u003c/b\u003e Estradiol Hemihydrate\u003c/p\u003e\n\u003c/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eSynonyms:\u003c/b\u003e 17\u0026beta;-Estradiol Hemihydrate; Oestradiol Hemihydrate\u003c/p\u003e\n\u003c/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eMolecular Formula:\u003c/b\u003e C₁₈H₂₄O₂ \u0026middot; \u0026frac12;H₂O\u003c/p\u003e\n\u003c/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eMolecular Weight:\u003c/b\u003e 281.39 g/mol (anhydrous estradiol: 272.38 g/mol)\u003c/p\u003e\n\u003c/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eChemical Class:\u003c/b\u003e Natural estrogen; \u003cb\u003efemale sex hormone\u003c/b\u003e\u003c/p\u003e\n\u003c/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eCAS Number:\u003c/b\u003e 50-28-2 (estradiol); hemihydrate form used in pharmaceutical preparations\u003c/p\u003e\n\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003eEstradiol hemihydrate is the \u003cb\u003ehydrated crystalline form of 17\u0026beta;-estradiol\u003c/b\u003e, the principal endogenous estrogen in humans, widely used in pharmaceutical formulations due to \u003cb\u003eimproved stability and handling characteristics\u003c/b\u003e compared with the anhydrous form.\u003c/p\u003e\n2. Structural Characteristics\n\u003cp\u003eEstradiol hemihydrate consists of:\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003eThe \u003cb\u003eestrane steroid nucleus\u003c/b\u003e\u003c/p\u003e\n\u003c/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003...
