Synonyms: Calcium salt of a partly O-carboxymethylated cellulose, Carboxymethylcellulose Calcium CAS Number: 9050-04-8, Molecular Weight: ----, Chemical Formula: ----, EINECS EC Number: 618-566-8, FEMA: ----, Carmellose Calcium BP Ph Eur Grade Specifications Ph Eur --- CAS 9050-04-8 Action and use: Excipient in pharmaceutical products; bulk laxative. DEFINITION Calcium salt of a partly O-carboxymethylated cellulose. CHARACTERS Appearance: White or yellowish-white powder, hygroscopic after drying. Solubility: Practically insoluble in acetone, in alcohol and in toluene. It swells with water to form a suspension. IDENTIFICATION A. Shake 0.1 g thoroughly with 10 ml of water. Add 2 ml of dilute sodium hydroxide solution and allow to stand for 10 min (solution A). Dilute 1 ml of solution A to 5 ml with water. To 0.05 ml add 0.5 ml of a 0.5 g/l solution of chromotropic acid, sodium salt in a 75 per cent m/m solution of sulphuric acid and heat on a water-bath for 10 min. A reddish-violet colour develops. B. Shake 5 ml of solution A obtained in identification test A with 10 ml of acetone. A white, flocculent precipitate is produced. C. Shake 5 ml of solution A obtained in identification test A with 1 ml of ferric chloride solution. A brown, flocculent precipitate is formed. D. Ignite 1 g and dissolve the residue in a mixture of 5 ml of acetic acid and 10 ml of water. Filter if necessary and boil the filtrate for a few minutes. Cool and neutralise with dilute ammonia. The solution gives reaction of calcium. TESTS Solution S: Shake 1.0 g with 50 ml of distilled water, add 5 ml of dilute sodium hydroxide solution and dilute to 100 ml with distilled water. Alkalinity: Shake 1.0 g thoroughly with 50 ml of carbon dioxide-free water and add 0.05 ml of phenolphthalein solution R . No red colour develops. Chlorides: Maximum 0.36 per cent. Sulphates: Maximum 1 per cent. Heavy metals: Maximum 20 ppm. Loss on drying: Maximum 10.0 per cent, determined on 1.000 g by drying in an oven at 105C for 4 h. Sulphated ash: 10.0 per cent to 20.0 per cent, determined on 1.0 g in a platinum crucible. Carboxymethylcellulose Calcium USP Grade Specifications : Cellulose, carboxymethyl ether, calcium salt; Cellulose carboxymethyl ether calcium salt CAS 9050-04-8 UNII: UTY7PDF93L DEFINITION Carboxymethylcellulose Calcium is the calcium salt of a polycarboxymethyl ether of cellulose. IDENTIFICATION A . Procedure Sample solution: Shake thoroughly 0.1 g of Carboxymethylcellulose Calcium with 10 mL of water, followed by 2 mL of 1 N sodium hydroxide, and allow to stand for 10 min. [Note- Save the unused portion of the Sample solution for use in Identification tests B and C.] Analysis: To 1 mL of the Sample solution add water to make 5 mL. To 1 drop of the resulting solution, add 0.5 mL of chromotropic acid, and heat in a water bath for 10 min. Acceptance criteria: A red-purple color develops. B . Procedure Analysis: Shake 5 mL of the Sample solution prepared in Identification test A with 10 mL of acetone. Acceptance criteria: A white, flocculent precipitate is formed. C . Procedure Analysis: Shake 5 mL of the Sample solution prepared in Identification test A with 1 mL of ferric chloride. Acceptance criteria: A brown, flocculent precipitate is formed. D . Identification Tests-General: Analysis: Ignite 1 g to ash, dissolve the residue in 10 mL of water and 5 mL of 6 N acetic acid, and filter, if necessary. Boil the filtrate, cool, and neutralize with 6 N ammonium hydroxide. Acceptance criteria: Meets the requirements. About the Company GST Registration Date: 2023 Legal Status of Firm: Limited Company Number of Employees: 51 To 100 People Annual Turnover: 25 - 100 Cr company-description: Anmol Chemicals is a manufacturer supplier exporter of Pharmaceutical Excipients, Food Grade Chemicals and it offers materials as per IP BP EP Ph Eur USP NF JP FCC Food Grade as per the the latest monograph at best prices. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Some API, Food Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, EP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs. We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP BP USP NF Ph Eur EP JP), Specialty Chemicals (Pure/Reagent), Mineral Fortifiers (FCC). Our manufacturing facility is FDA approved and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) is available. Solid materials can be customized for particle size, shape, and bulk density. We observe WHO Good Manufacturing Practices and Good Laboratory Practices. We are a government-recognized STAR Export House and "Authorised Economic Operator (AEO)" per Indian Customs.
