Piperine is a naturally occurring alkaloid obtained from piper nigrum, piper longum belonging to Piperaceace family . Piperine has a potential application in drug discovery and development in diverse human ailments viz. Anti-allergic, Anti-inflammatory, decreases levels of cytokines like IL-1b, TNF-α, and PGE2 and increases level of anti-inflammatory cytokines like IL-10[29]. Piperine is known to exhibit diverse CNS activities, namely anti-epileptic, antidepressant, and in various neurodegenerative disorders, improves mood, cognitive function by increasing dopamine and serotonin, Increases the bioavailability of various drugs, anti-diarrhoeal activity (by inhibition of prostaglandins), Anticancer properties. 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